|
KMID : 0895820070170020055
|
|
Journal of Oriental Rehabilitation Medicine
2007 Volume.17 No. 2 p.55 ~ p.66
|
|
|
The Influence of Bee Venom on Immune-modulation in Rheumatoid Arthritis
|
|
Lee Han-Sung
Lee Jong-Soo
Chung Seok-Hee
|
|
|
Abstract
|
|
|
Objectives :In the present study we hypothesized that the change of cytokine profiles can be identified after bee venom treatment and that is associated with modulation of immune-activating cells which have pathogenic role in rheumatoid arthritis.
Methods : T cells and monocytes were isolated from human peripheral blood. Isolated monocytes were further induced to differentiate into dendritic cell(DC). Isolated T cells and differentiated DC were activated with phorbol 12-myristate 13-acetate(PMA) and lipopolysaccharide(LPS), respectively. Bee venom(BV) added to each experiment group. Intracytoplasmic stain of T cells and morphologic observation, surface molecule analysis of DC were performed before and after cellular activation.
Results :Pro-inflammatory cytokine was reduced whereas anti-inflammatory cytokine was increased with BV treatment in T cells. In DC, morphologic maturation and surface molecule increase by LPS was also inhibited by BV.
Conclusion : BV may be an effective treatment in rheumatoid arthritis through its immune-modulating effect.
|
|
|
KEYWORD
|
|
|
Bee benom, Rheumatoid arthritis, Immunotherapy, Regulatory T cell
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|